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KMID : 0364820100460010052
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Korean Journal of Microbiology
2010 Volume.46 No. 1 p.52 ~ p.62
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Efficacy of Mixture of Lactic Acid Bacteria (LAB) and Bifidobacteria Supplement in the Management of Constipation; Demonstration of Functionality in Animal and Clinical Trials
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Kim Jung-Rae
Lee Do-Kyung
Baek Eun-Hye
An Hyang-Mi
Yang Hwan-Jin
Kim Mi-Jin
Yun Mi-Eun
Choi Kyung-soon
Chung Yi-Jung
Oh Pok-Ja
Chung Myung-Jun
Ha Nam-Joo
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Abstract
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The aim of this study was to evaluated the efficacy of mixture of Lactic Acid Bacteria (LAB) and bifidobacteria supplement, which are contained with Lactobacillus acidophilus, Bifidobacterium longum SPM1205, and Pediococcus pentosaceus for the management of constipation in animal model and clinical trials. 5 ICR mice and 4 female constipation subjects were orally taken mixture of LAB and bifidobacteria for 2 weeks. We investigated the number of fecal LAB and harmful enzymes activities before and after mixture of LAB and bifidobacteria application. As a result, fecal LAB count was increased
and harmful enzymes activities of intestinal microflora were generally decreased after mixture of LAB and bifidobacteria application. Also, 61 female subjects were randomly assigned to receive either mixture of LAB and bifidobacteria or lactose and were taken three times a day for 2 weeks. Then, we analyzed mixture of LAB and bifidobacteria effect through the questionnaires. Daily consumption of this mixture of LAB and bifidobacteria improved the constipation in constipation group (56.3%) compared with lactose application group (26.7%). Furthermore, after mixture of LAB and bifidobacteria
treatment, frequency of hard stool decreased from 0.22 to 0.03. These results indicated that mixture of LAB and bifidobacteria application is effective to improve the constipation.
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KEYWORD
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animal models, clinical trials, management of constipation, mixture of lactic acid bacteria (LAB) and bifidobacteria supplement
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